Bethesda's answer to Hearthstone has gone into Open Beta so anyone is now free to check it out. It adds some interesting things, such as having two lanes and an ability to pull a card at random after taking a certain number of hits which can be played immediately. You also get to play with a bigger deck between 50 and 70 cards and it uses a colours system like Magic. The other difference is their equivalent to the Arena mode can be played against the AI. So it certainly sounds like it is trying some different stuff and is getting some positive press. Everything else such as the ability to disenchant, and the cost of packs is similar.
Just visit the link below if you want to give it a try. I'll probably give it a shot at some point this weekend and post some thoughts.